This is “Where Things Grow Back!”

We are currently involved in a Research Study on a special process of purifying bone marrow or BMA using a system designed by Emcyte Corporation. We are working with Bio Sciences Research Center at Harvard and offering a great opportunity for special pricing on treatment. Call our office for details.

Prolotherapy & Platelet Rich Plasma with

 Wellington Chen, M.D., Raette Hall PA-C,  John Lieurance, D.C. & Alex Smithers, AP, DOM & the Gecko Team.

Years of experience and training in the field of regenerative injections are why you might choose these physicians as your doctors for these treatments. Platelet Rich Plasma Therapy or PRP is Prolotherapy using your own blood. Your blood is placed into a machine that looks like a record player. The platelet rich plasma is spun down and this solution is then injected into area’s that are damaged or arthritic.

Click on one of the button’s below to explore videos and information on how Gecko’s Regenerative therapies work on some specific conditions.

Gecko Joint & Spine is Sarasota’s Regenerative Clinic!

Wellington Chen, M.D. attended Northestern University, University of Pennsylvania, University of Florida, and UF Dept. of Anesthesiology.

Emergency Medical Work includes: Citrus Memorial Hospital, Inverness, FL, Encino Hospital, Ca (Dir of Emergency Medicine, 1978 – 1983) , Glendale Memorial Hospital, Venice HospitalFlorida , Doctors Hospital, Sarasota Englewood Hospital, Florida, Citrus Memorial Hospital,Crystal River, Florida.

He studied through the University of Wisconsin as well as with the orthomolecular Institute on both Prolotherapy and Platelet Rich Plasma Therapy. He has been performing Prolotherapy for 10 years and was the first to offer PRP as well as adipose and bone marrow stem cell treatments in Sarasota, Florida.

Alex Smithers, DOM, AP 

AlexReceived his graduate degree from the East West College of Natural Medicine where he excelled in his understanding and practical application of both Eastern and Western Medicine.In addition to his Oriental Medical knowledge, he has an equal proficiency in Western Medical diagnosis, which resulted under the tutelage of the great Dr. Banerjee M.D. FACE (Listed in Best Doctors of America). Dr. Smithers is a board certified Doctor of Oriental Medicine and Acupuncture Physician. A native of Sarasota, Dr. Smithers’ family has a long and well-known history in the community. Dr. Smithers work with Prolozone, Prolotherapy and other regenerative therapies as well as High Definition Ultrasound. His knowledge of both Eastern and Western medicine gives him a special gift in this field of medicine.

John A. Lieurance, D.C.

has been using Musculoskeletal Ultrasound since 1998 and has extensive training through Gulf Coast Ultrasound Institute, American Association of Orthopedic Medicine and the American Osteopathic Association of Prolotherapy Regenerative Medicine. Dr. Lieurance often assists in the diagnosis of the injuries at Gecko Joint and Spine as well as the guidance of the needle when the treatment is injected which aids in the precision of the treatment. Dr. Lieurance and Dr. Chen have been working as a team for 8 years. He attended Parker College of Chiropractic and has a Bachelor in Anatomy from the University of the State of New York. He received his Naturopathic degree in 2001 from St. Lukes School of Medicine.   Dr. Lieurance has a gift for difficult cases where other practitioners have failed. His Chiropractic, Naturopathic and use of Ultrasound gives the center an edge in the treatment of difficult cases. He has been working along side Prolotherapy procedures for 17 years  after his Chiropractic career was saved through prolotherapy in 1997.

“We are commited to offering the finest and most advanced regenerative injection therapies to my patients in a warm, caring and of course most comfortable/ pain free way possible.”

About PRP therapy.

This is a video explaining PRP.

This video shows how ligament damage can often be the cause of chronic neck pain.

Watch this video on PRP regenerating Cartilage.


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Chiropractor Gets PRP injections for Chronic Back Pain from Arthritis

Screen Shot 2015-03-29 at 1.13.04 PMEven Chiropractors can’t escape the fact that adjustments won’t regenerate damaged connective tissue in the spine and pelvis (SI joints). This connective tissue is the stuff that hold everything together and when it’s damaged it leads to instability which then ends in painful arthritis. After years of pain and disability Doc gets Platelet Rich Plasma Prolotherapy at Gecko Joint and Spine in Sarasota Florida Chiropractor Gets PRP injections for Chronic Back Pain from Arthritis.

Free consult by calling (941) 330-8553

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PRP & ozone in Sarasota for arthritis of knee & hip under ultrasound guidance

This was a patient in Sarasota Florida with hip and knee arthritis that received platelet rich plasma with honey matrix and ozone or prolozone. These amazing regenerative injections where done under ultrasound guidance. Watch her post ultrasound scan and the improvement that was seen after just one treatment!

Call (941) 330-8553 for a free in office or phone consultation with on of our doctors.

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Stem Cells Treatment for Ankylosing Spondylitis in Sarasota Florida

Stem Cells Treatment for Ankylosing Spondylitis

Ankylosing Spondylitis is a form of spondyloarthritis, a chronic, inflammatory arthritis and autoimmune disease. It mainly affects joints in the spine and the sacroiliac joint in the pelvis, and can cause eventual fusion of the spine.

Stem Cells  Treatment for Ankylosing Spondylitis

This is a systemic rheumatic disease, meaning it affects the entire body. Approximately 90% of AS patients express the HLA-B27 genotype, meaning there is a strong genetic association. However, only 5% of individuals with the HLA-B27 genotype contract the disease. Tumor necrosis factor-alpha (TNF ?) and IL-1 are also implicated in ankylosing spondylitis. Auto antibodies specific for AS have not been identified. Antineutrophil cytoplasmic antibodies ANCA are associated with AS, but do not correlate with disease severity.The association of AS with HLA-B27 suggests the condition involves CD8 T cells, which interact with HLA-B.

Ankylosing Spondylitis treatment mumbai

Clinical Presentation:

  • Ankylosing Spondylitis begins with pain in the lower spine and sacroiliac joints with muscle spasm, often spreading to the upper back and neck and improved by exercise.
  • Chronic pain and stiffness in the lower part of the spine or sometimes the entire spine with pain referred to one or other buttock or the back of thigh from the sacroiliac joint.
  • Inflammation of the eye causing eye pain.
  • Fatigue and sometimes nausea.
  • Lung fibrosis.
  • Escatsia of the sacral nerve root sheaths may occur causing pain and swelling of large limb joints.

Now, such incurable diseases can be treated by Stem Cell Therapy. Where Stem cells are being taken from patient’s own bone marrow, Adipose derived fat stem cells, peripheral blood derived stem cells or Umbilical cord blood-derived & placenta-derived immune rejection free stem cells.

Stem cells are immature, unprogrammed, unspecialised precursor cells that can grow and change to make new cells and tissues. They can transform into about 250 types of specialised cells that make up a human being.

Ankylosing Spondylitis treatment India

In recent years, scientists have developed a new method for treating autoimmune disease like Ankylosing Spondylitis, with Mesenchymal stem cells implantation. It has several advantages:

  • The Mesenchymal stem cells can differentiate into immune cells, repair the immune system, some of them after implantation can repair and replace the damaged cells and tissue.
  • The Mesenchymal stem cells can secrete different kinds of cell factors which can withhold inflammatory mediators and cells, repair damaged joints and the synovium, and block the development of the disease effectively.
  • There is no risk of a rejection reaction, it is safe and effective and the most important thing is that the stem cells treatment has a very measurable, positive effect.

We hope in future by using the stem cell culture we can produce the artificial vertebrae and can treat the Ankylosing Spondylitis diseases.

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Regeneration of meniscus and hyaline cartilage in a arthitic knee treated with intra-articular implantation of autologous mesenchymal stem cells from bone marrow and or adipose derived (fat).

Regeneration of meniscus and hyaline cartilage in a arthitic knee treated with intra-articular implantation of autologous mesenchymal stem cells from bone marrow and or adipose derived (fat).

Stem Cell Treatment for Cartilage Stem Cell Treatment for Cartilage

kneecap
Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types,including: osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells).

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Mesenchymal stem cells (MSCs) are adult autologous stem cells found in the bone marrow. However, mesenchymal stem cells can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube, and fetal liver and lung. Mesenchymal stem cells are a distinct entity to the mesenchyme, embryonic connective tissue which is derived from the mesoderm and differentiates to form hematopoietic stem cells. Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal and human models to regenerate articular cartilage and bone.

Current treatment for cartilage damage in osteoarthritis focuses on surgical interventions such as arthroscopic debridement, microfracture, and cartilage grafting/transplant, total joint replacement. These procedures have more complications than hoped, are invasive, and often entail a prolonged recovery time. MSCs can be harvested from the iliac crest through Bone Marrow Aspiration, activated using the patient’s own growth factors from platelet’s (PRP), then successfully implanted to increase cartilage volume in an adult human knee.

We present a review highlighting the developments in cellular and regenerative medicine in the arena mesenchymal stem cell therapy by successful harvest and transplant of autologous mesenchymal stem cells into an adult human knee, hip, ankle, shoulder, fingers, facets in the spine and wrists that repairs the cartilage, ligaments & meniscal damage & lubricate the joint space.

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Applications of Mesenchymal stem cell-based therapies in Rheumatoid Arthritis.

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Ozone injections for herniated disc. Prolozone used for chronic back pain from disc damage.

Below you will find some technical information on the use of ozone injections into and round the spinal discs of the back to promote recovery from chronic back pain. Ozone is being widely used and accepted as an alternative treatment to surgery and may be much better option due to it’s less invasive approach. It is more widely used out side of the USA due to political power of the surgical and pharmacology influences that govern the education and exposure to medical professionals here. There are 2 approaches the direct and the indirect approach.

The direct approach is carried out under radioscopic control: the needle is

inserted in the centre of the pathologic intersomatic space just before direct

insufflation of the gas mixture.  An expert can do it in about 10

min. After a rest of 10-15 min, the patient can get up and often he/she is

amazed by the disappearance of the pain, as occurs after nucleoplasty. If

necessary, the application can be repeated a second time before changing the

approach.

Good results have been obtained after either intradiscal or intraforaminal

injection of a variable volume (3-15 ml) of gas at an O3 concentration of 27-

30 mcg/ml. Several thousand patients have been treated, with a success rate

of 54-86% ( Jucopilla et al., 2000; Bonetti et al., 2001; Fabris et al., 2001;

Petralia et al., 2001; Alexandre et al., 2002). An extensive study had been

performed in 600 patients, who had failed to respond to conservative

management (Andreula et al., 2003): 70.3% of the first half of patients,

treated only with ozone, showed a good outcome. This was further improved

(78.3%) in the remaining 300 patients, by combining ozone treatment with a

periganglionic injection of corticosteroid and anaesthetic. Unfortunately

controls (either oxygen or oxygen-corticosteroid-anaesthetic alone) were not

evaluated, probably, for ethical reasons. Nonetheless, from a scientic point

of view, it will be important to perform a randomized study to evaluate the

role of the needle, oxygen and so forth, which are probably relevant.

It remains unclear how ozone acts. One real possibility, previously

discussed at length (Bocci 1998a, 1999), is that ozone dissolves in the

interstitial water and reacts immediately, generating a cascade of ROS,

among which H2O2 and possibly the hydroxyl radical, which is most

reactive. The hydroxyl radical can react with carbohydrates and amino acids

composing proteoglycans and collagen type I and II, major components of

the degenerate nucleus pulposus, leading to its breakdown (McCord, 1974;

Curran et al., 1984; Hawkins and Davies, 1996; Bocci et al., 2001b;

Leonardi et al., 2001). These studies, as well as those performed on human

blood, have been carried out using the Electron Paramagnetic Resonance

(EPR) spin trapping technique (Ueno et al., 1998; Bocci et al., 2001b).

Consequently, reabsorption of hydrolytic products and water may lead to

progressive shrinkage and disappearance of the herniated material. Reduced

mechanical irritation decreases the sensitivity of nerve axons, but

nociceptors are also excited by endogenous algesic substances released

during perineural ischaemia or neural inflammation present in the spinal

ganglion and neural roots (Willis, 1995). Thus, more than the mechanical

compression as primum movens, it is the inflammatory reaction that

sustains chronic pain by releasing PLA2, several proteinases and

cytokines. The continued release of ROS, PGE2, serotonin, bradykinin,

cathepsins, IL-1, IL-6, substance P and TNF alpha causes oedema, possibly

demyelination and increased excitability of nociceptors (Fields, 1986).

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Indeed, it has been observed that, in absence of inflammation, even a large

hernia can be painless. Moreover, the hernia may remain after an operation

(as seen radiographically), but the pain disappears once the inflammatory

disorder dies down. Interestingly, epidural injections of the antiinflammatory

methylprednisolone transitorily improve leg pain and sensory

deficits in patients with sciatica due to a herniated disc (Carette et al., 1997).

Table 7 intends to summarize the complex reparative process induced by

ozone used in substitution or in combination with orthodox remedies.

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Gecko Info Pic

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Osteoarthritis and the use of Ozone Injections for regeneration of cartilage and ligaments explained. | Sarasota, Florida doctor uses ozone for arthritis

Wear and tear of joints and break down of cartilage called osteoarthritis. The

pathophysiology of these diseases is complex and characterized by

the softening and even distruction of the articular cartilage, with increased

matrix degradation due to collagenase and proteoglycanases. The enzymes

may be secreted by activated chondrocytes and monocytes, which release IL-

1 and TNF

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Using adipose derived stem cells in treatments for arthritis, muscle and tendon tears.

The above picture is a study done in Oct. 2012 showing the difference in doing nothing , PRP , ADSC (fat), and BMSC (bone marrow) on cartilage damage. They looked at 6 & 12 wk’s. This evidence supports the use of BMA and ADSC in moderate to severe arthritis for the regeneration of cartilage.

The above picture is a study done in Oct. 2012 showing the difference in doing nothing , PRP , ADSC (fat), and BMSC (bone marrow) on cartilage damage. They looked at 6 & 12 wk’s. This evidence supports the use of BMA and ADSC in moderate to severe arthritis for the regeneration of cartilage.

At Gecko Joint and Spine we use autologous adipose derived stem cells in our treatments. Adult Stem Cells (ASCs), by definition, are unspecialized or undifferentiated cells that not only retain their ability to divide mitotically while still maintaining their undifferentiated state but also, given the right conditions, have the ability to differentiate into different types of cells including cells of different germ-origin – an ability referred to as transdifferentiation or plasticity.1,2 In vitro, the conditions under which transdifferentiation occurs can be brought about by modifying the culture medium in which the cells are cultured. In vivo, the same changes are seen when the ASCs are transplanted into a tissue environment different to their own tissue-of origin. Though the exact mechanism of this transdifferentiation of ASCs is still under debate, this ability of ASCs along with their ability to self-renew is of great interest in the field of Regenerative Medicine as a therapeutic tool in being able to regenerate and replace dying, damaged or diseased tissue.

Clinically, however, there are a few criteria that ASCs need to fulfill before they can be viewed as a viable option in Regenerative Medicine. These are as follows:3

  1. Abundance in numbers (millions to billions of cells)
  2. Ease of harvest (through minimally invasive procedures)
  3. Ability to differentiate into multiple cell types (which can be regulated and reproduced in vitro)
  4. Safe to transplant to a different site of the autologous host or even an allogenic host.
  5. No conflict with current Good Manufacturing Principles (during procurement, culture or transplantation)

To find out more about autologous derived adipose stem cells and how they might work to regenerate your arthritis or muscle or tendon tear then you can call our office at (941) 330-8553 or email AskDrGecko@Gmail.com

 

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New and emerging treatments for osteoarthritis management: will the dream come true with personalized medicine? |Stem Cells | PRP in Sarasota Florida | Osteoarthritis | alternative to Joint Replacment

Stem Cells and PRP in Sarasota Florida for Osteoarthritis and as an alternative to Joint Replacment.

Abstract

INTRODUCTION:

Osteoarthritis (OA) is a dynamic process involving the main tissues of the joint for which a global approach should be considered. No disease-modifying OA drug (DMOAD) has yet been approved. New therapeutic strategies are needed that would be cost effective by reducing the need for pharmacological interventions and surgical management while targeting specific pathways leading to OA. The treatment landscape of OA is about to change based on new agents having shown some structural effects and emerging therapies with DMOAD effects.

AREAS COVERED:

In this review based on a Medline (via PubMed) search, promising new and emerging therapies with a potential structural effect (DMOAD) will be discussed including growth factors, platelet-rich plasma, autologous stem cells, bone remodeling modulators, cytokine inhibition, gene therapy, and RNA interference.

EXPERT OPINION:

DMOAD development should focus on targeting some phenotypes of OA patients evidenced with sensitive techniques such as magnetic resonance imaging, as a single treatment will unlikely be appropriate for all OA patients. This will allow the development of DMOADs based on personalized medicine. An exciting new era in DMOAD development is within reach, provided future clinical trials are sufficiently powered, systematically designed, use the appropriate evaluation tools, and target the appropriate categories of OA patients.

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Explore Sciatica from a more holistic view and the 5 causes of it. |Prolotherapy for sciatica | PRP for Sciatica | Sarasota Doctor

There is too much emphasis on the lumbar disc when it comes to Sciatic and little attention to the other causes of leg pain. Out of 5 known causes of leg pain only one is from the nerve root. 

Radicular pain or “radiculopathy” (sometimes also referred to as a “”pinched nerve”) is often described by patients as a deep pain that travels down the leg. This pain is often accompanied by numbness or tingling, and muscle weakness in the limb.

The most common example of this type of problem is sciatica. This radiates down the leg along the sciatic nerve. Sciatica follows the path down the back of the thigh, into the calf and then into the foot via branches of the nerve.

Radicular pain may be caused by an injury to the spine. It may be from impact injuries that cause compression in the vertebrae, such as those in sports related injuries or motor vehicle accidents, i.e., disc herniation. Or it may be caused by a degenerative process discussed above such as stenosis or Degenerative Disc Disease.

It is essential to perform a physical examination in cases of referred pain to isolate the problem.

It may actually be a ligament injury that appears to be a nerve impingement and ligament trigger points may refer pain in a manner similar to radiculopathy.

This is why relying on an MRI as the sole diagnostic tool could lead to unnecessary surgery. An MRI may show a pre-existing condition that never caused pain. If surgery was performed to correct this condition and pain was actually generated by a ligament sprain, the surgery would fail.

A physical examination and conservative treatment will help determine if this is a ligament injury or a nerve problem.

It is important for the patient to know in cases of radiating pain that an MRI that indicates slippage of the vertebrae (Spondylolisthesis), an arthritic condition, or a bulging disc is NOT necessarily an indication that surgery is needed.

Sciatica Diagnosis MRI

We typically have patients come into our office with stacks of MRIs, CT Scans and x-rays to confirm the label of Degenerative Disc Disease placed on them by other medical professionals. For example, a woman once came into our office. She had in essence become the living, breathing “embodiment,” of the problem that showed up on her film. When she came in, all she could do was talk about her degenerative disc disease. This woman had pain in her groin and her back. When we told her we were going to examine her to determine if this was indeed her problem, she had a lot of difficulty comprehending that her pain may not come from her Degenerative Disc Disease at L-5, S-1 because she had already been diagnosed as needing surgery. There have been many studies and papers written on the accuracy or correctness of diagnosis based on an MRI reading.

We know from studies that half the people after a certain age show disc problems on film but they reported they had no pain.

So if someone has a diagnosis from an MRI the first thing we do is see if that is REALLY where the pain is coming from. To practice good medicine we need to rely on MRI, x-ray and CT scans. But we also need to use our hands to find out where the pain is coming from, being careful to gently press on the suspect area causing pain. When the physician’s touch elicits an intense pain spot, known as a trigger point or tender point, this may be a good area to do Prolotherapy.

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