This is “Where Things Grow Back!”

New Study shows 90% results for moderate to severe osteoarthritis at 12 months after Stem Cell Injection.  

If you have been told you need a joint replacement then call us @ (941) 330-8553 for more information or to attend a free seminar or phone consultation.

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Prolotherapy & Platelet Rich Plasma 

Years of experience and training in the field of regenerative injections are why you might choose these physicians as your doctors for these treatments. Platelet Rich Plasma Therapy or PRP is Prolotherapy using your own blood. Your blood is placed into a machine that looks like a record player. The platelet rich plasma is spun down and this solution is then injected into area’s that are damaged or arthritic.

Click on one of the button’s below to explore videos and information on how Gecko’s Regenerative therapies work on some specific conditions.

Gecko Joint & Spine is Sarasota’s Regenerative Clinic!


“We are commited to offering the finest and most advanced regenerative injection therapies to my patients in a warm, caring and of course most comfortable/ pain free way possible.”

About PRP therapy.

This is a video explaining PRP.

This video shows how ligament damage can often be the cause of chronic neck pain.

Watch this video on PRP regenerating Cartilage.

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7 Secrets of Regenerative Therapy – Honey Matrix

Making PRP or platelet rich plasma in Sarasota Florida work better through improved scaffolding properties in the honey matrix called fibrin. These act as tiny little struts that hold the graft in place long enough for the new tissue to regenerate the cartilage or tendon or muscle for knee, hip, ankle or spinal procedures. Advanced Rejuvenation is a top regenerative orthopedic group doing PRP stem cells and prolotherapy in sarasota florida.

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7 Secrets to Regenerative Therapy – Prolozone

Prolozone Therapy
What Is Prolozone Therapy?

Prolozone is a form of non-surgical ligament reconstruction and is a permanent treatment for chronic pain. Prolozone is a connective tissue injection therapy of collagen producing substances and ozone gas which can reconstruct damaged or weakened connective tissue in and around joints. These substances are injected into the damaged connective tissue in and around a joint to rebuild the damaged areas.

By repairing the connective tissue this is all that is needed to permanently reverse chronic pain.

Prolozone Therapy is an injection technique similar to prolotherapy that uses ozone. The use of ozone causes the joint to heal much more quickly than in traditional prolotherapy. This is because ozone is a highly reactive molecule and when injected into a joint capsule it is able to stimulate the fibroblastic joint repairing abilities.

Prolozone is derived from the word ozone and the Latin word “proli” which means to regenerate or re-build. It literally means re-building tissues with ozone. It is important to understand what the word prolozone actually means. “Prolo” is short for proliferation, because the treatment causes the proliferation (growth, formation) of new ligament tissue in areas where it has become weak.

Ligaments are the structural “rubber bands” that hold bones to bones in joints – acting like the body’s shock absorbers. Ligaments can become weak or injured and may not heal back to their original strength or endurance. Ligaments will also not tighten on their own to their original length once injured. This is largely because the blood supply to ligaments is limited, and therefore healing is slow and not always complete. To further complicate this, ligaments also have many nerve endings, and therefore the person will feel pain at the areas where the ligaments are damaged or loose.

We can think of our joints as the hinge on a door. Until the hinge is fixed the door just isn’t going to open or close right and it’s the same exact story with our joints. If we are athletic or if we are just getting older there is some gradual and natural degeneration of the moving parts of the body due to ongoing recurrent mechanical stress, and failure of tissues to repair. This can come from lack of nutrients, lack of circulation, aging and inflammation. When this happens the ligaments, tendons, and cartilage become dehydrated and weaker. This results in laxity and more abnormal mechanical stress and shearing forces on the joint. Abnormal shearing forces and torsion cause more joint dysfunction. This leads to a progressive separation of the ligaments from the superficial covering on the bone called the periosteum. This pulling on the periosteum creates a space, which the body fills in with new bone. These new parts of bone are called osteophytes. They are the premier signs of degenerative arthritis in & around the joint. Osteophytes and joint laxity result in a reduced range of motion, which causes strain on surrounding muscles which then become either over or under worked leading to more dysfunction & pain.

Prolozone causes repair and tightening of the lax structures, partially torn connective tissue and ligaments. Prolozone halts the pain/inflammation cycle. This allows for better circulation, increased blood flow carrying nutrition, and hydration of the damaged tissues. This allows for a healing environment within the joint to develop and results in increased range of motion and decreased pain.

Who is a candidate for this program?

Low Back Pain, Shoulder pain, Rotator Cuff Tears, Knee injuries, Individuals wanting to avoid knee and hip replacement. People having PRP and when it is indicated to prepare a joint for grafting using stem cell or PRP therapy.

Because Prolozone treatments also result in cartilage regeneration, the technique is also remarkably effective even for severe cases of osteo-arthritis of the hip or knee. The good thing about Prolozone therapy is that it is not just a treatment for pain. The results can actually represent a long term fix.

Once the doctor takes a detailed history of your injury and looks at your MRI report she will be able to tell you if Prolozone is right for you.

Conditions commonly treated with Prolozone Therapy include:

Chronic back pain
Bulging or herniated disks
Overused joint injuries
Weakened joints from prior injury
How does it work?

Pain will persist as long as connective tissue in a joint remains damaged. Connective tissue can be scarred, torn, or overly stretched. Prolozone injections stimulate tissue to repair itself, strengthening and tightening, and ultimately stabilizing the joint. Prolozone therapy involves the injections of ozone into soft tissues, ligaments, and tendons. This causes a localized inflammation in these weak areas, which then increases the blood supply and flow of nutrients, the stimulation of anabolic cells, fibroblasts, osteoblasts, and chondroblasts. These effects stimulate the tissue to repair itself, strengthening and tightening, and thereby stabilizing the area.

What do I have to know before I get started?

It is important that the patient use no anti-inflammatory medications before and during the 48 hours after the injection. For this same reason, areas that have been treated with steroid or cortisone injections cannot be treated with Prolozone until the injections have worn off.

What can I expect?

The response to treatment varies from individual to individual, and depends upon one’s healing ability and level of injury. Some people may only need one to two treatments, while others may need as many as six or seven. Once you being treatment, the doctor can analyze how you are responding, and will then be able to give you an accurate estimate of what you can expect from further treatments. The injection process is repeated every 1-2 weeks until maximum improvement is noted. Prolozone Therapy typically results in a complete absence of symptoms, even in severe pain conditions that have been present for years. And, the most amazing thing about it is that the results usually represent a long term fix.


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How are the cells deployed into a patient?

How are the cells deployed into a patient?

How are the cells deployed?Depending on the type of treatment required, stem cells can be injected through veins, arteries, into spinal fluid, subcutaneously, or directly into joints or organs. All of these are considered minimally invasive methods of introducing the stem cells. Stem cells injected intravenously are known to “seek out and find” (see photo) areas of tissue damage and migrate to that location thus potentially providing regenerative healing. Intravenously injected stem cells have been shown to have the capability of crossing the “blood-brain barrier” to enter the central nervous system and they can be identified in the patient’s body many months after deployment. Note yellow arrow showing the stem cells concentrated in the patient’s hand where he had a Dupytren’s contracture (Dupuytren’s contracture is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract).

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Why does Gecko Joint and Spine use liposuction fat rather than bone marrow as a source of stem cells?

Why does Gecko use liposuction fat rather than bone marrow as a source of stem cells?

Bone marrow sampling yields approximately 5,000 – 60,000 cells that are then cultured over several days to perhaps a few million cells prior to deployment (injection into the patient). Recent advances in stem cell science have made it possible to obtain high numbers of quality multi-potent (able to form numerous other tissues) cells from a person’s own liposuction fat. Gecko uses new technology to process this fat to yield approximately five hundred thousand to one million stem cells per cc of fat, and therefore, it is possible to obtain as many as 10 to 40 million cells from a single treatment. These adipose derived stem cells can form many different types of cells when deployed properly including bone, cartilage, tendon (connective tissue), muscle, blood vessels, nerve tissue and others. We also often with add the bone marrow stem cells into the injection which we call Marrapose. There are signaling compounds in Marrow that help the regenerative process along a bit seeing the shear volume of stem cells from the adipose bolsters the healing.

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Chiropractor Gets PRP injections for Chronic Back Pain from Arthritis

Screen Shot 2015-03-29 at 1.13.04 PMEven Chiropractors can’t escape the fact that adjustments won’t regenerate damaged connective tissue in the spine and pelvis (SI joints). This connective tissue is the stuff that hold everything together and when it’s damaged it leads to instability which then ends in painful arthritis. After years of pain and disability Doc gets Platelet Rich Plasma Prolotherapy at Gecko Joint and Spine in Sarasota Florida Chiropractor Gets PRP injections for Chronic Back Pain from Arthritis.

Free consult by calling (941) 330-8553

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PRP & ozone in Sarasota for arthritis of knee & hip under ultrasound guidance

This was a patient in Sarasota Florida with hip and knee arthritis that received platelet rich plasma with honey matrix and ozone or prolozone. These amazing regenerative injections where done under ultrasound guidance. Watch her post ultrasound scan and the improvement that was seen after just one treatment!

Call (941) 330-8553 for a free in office or phone consultation with on of our doctors.

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Stem Cells Treatment for Ankylosing Spondylitis in Sarasota Florida

Stem Cells Treatment for Ankylosing Spondylitis

Ankylosing Spondylitis is a form of spondyloarthritis, a chronic, inflammatory arthritis and autoimmune disease. It mainly affects joints in the spine and the sacroiliac joint in the pelvis, and can cause eventual fusion of the spine.

Stem Cells  Treatment for Ankylosing Spondylitis

This is a systemic rheumatic disease, meaning it affects the entire body. Approximately 90% of AS patients express the HLA-B27 genotype, meaning there is a strong genetic association. However, only 5% of individuals with the HLA-B27 genotype contract the disease. Tumor necrosis factor-alpha (TNF ?) and IL-1 are also implicated in ankylosing spondylitis. Auto antibodies specific for AS have not been identified. Antineutrophil cytoplasmic antibodies ANCA are associated with AS, but do not correlate with disease severity.The association of AS with HLA-B27 suggests the condition involves CD8 T cells, which interact with HLA-B.

Ankylosing Spondylitis treatment mumbai

Clinical Presentation:

  • Ankylosing Spondylitis begins with pain in the lower spine and sacroiliac joints with muscle spasm, often spreading to the upper back and neck and improved by exercise.
  • Chronic pain and stiffness in the lower part of the spine or sometimes the entire spine with pain referred to one or other buttock or the back of thigh from the sacroiliac joint.
  • Inflammation of the eye causing eye pain.
  • Fatigue and sometimes nausea.
  • Lung fibrosis.
  • Escatsia of the sacral nerve root sheaths may occur causing pain and swelling of large limb joints.

Now, such incurable diseases can be treated by Stem Cell Therapy. Where Stem cells are being taken from patient’s own bone marrow, Adipose derived fat stem cells, peripheral blood derived stem cells or Umbilical cord blood-derived & placenta-derived immune rejection free stem cells.

Stem cells are immature, unprogrammed, unspecialised precursor cells that can grow and change to make new cells and tissues. They can transform into about 250 types of specialised cells that make up a human being.

Ankylosing Spondylitis treatment India

In recent years, scientists have developed a new method for treating autoimmune disease like Ankylosing Spondylitis, with Mesenchymal stem cells implantation. It has several advantages:

  • The Mesenchymal stem cells can differentiate into immune cells, repair the immune system, some of them after implantation can repair and replace the damaged cells and tissue.
  • The Mesenchymal stem cells can secrete different kinds of cell factors which can withhold inflammatory mediators and cells, repair damaged joints and the synovium, and block the development of the disease effectively.
  • There is no risk of a rejection reaction, it is safe and effective and the most important thing is that the stem cells treatment has a very measurable, positive effect.

We hope in future by using the stem cell culture we can produce the artificial vertebrae and can treat the Ankylosing Spondylitis diseases.

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Regeneration of meniscus and hyaline cartilage in a arthitic knee treated with intra-articular implantation of autologous mesenchymal stem cells from bone marrow and or adipose derived (fat).

Regeneration of meniscus and hyaline cartilage in a arthitic knee treated with intra-articular implantation of autologous mesenchymal stem cells from bone marrow and or adipose derived (fat).

Stem Cell Treatment for Cartilage Stem Cell Treatment for Cartilage

Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types,including: osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells).


Mesenchymal stem cells (MSCs) are adult autologous stem cells found in the bone marrow. However, mesenchymal stem cells can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube, and fetal liver and lung. Mesenchymal stem cells are a distinct entity to the mesenchyme, embryonic connective tissue which is derived from the mesoderm and differentiates to form hematopoietic stem cells. Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal and human models to regenerate articular cartilage and bone.

Current treatment for cartilage damage in osteoarthritis focuses on surgical interventions such as arthroscopic debridement, microfracture, and cartilage grafting/transplant, total joint replacement. These procedures have more complications than hoped, are invasive, and often entail a prolonged recovery time. MSCs can be harvested from the iliac crest through Bone Marrow Aspiration, activated using the patient’s own growth factors from platelet’s (PRP), then successfully implanted to increase cartilage volume in an adult human knee.

We present a review highlighting the developments in cellular and regenerative medicine in the arena mesenchymal stem cell therapy by successful harvest and transplant of autologous mesenchymal stem cells into an adult human knee, hip, ankle, shoulder, fingers, facets in the spine and wrists that repairs the cartilage, ligaments & meniscal damage & lubricate the joint space.

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Applications of Mesenchymal stem cell-based therapies in Rheumatoid Arthritis.

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Ozone injections for herniated disc. Prolozone used for chronic back pain from disc damage.

Below you will find some technical information on the use of ozone injections into and round the spinal discs of the back to promote recovery from chronic back pain. Ozone is being widely used and accepted as an alternative treatment to surgery and may be much better option due to it’s less invasive approach. It is more widely used out side of the USA due to political power of the surgical and pharmacology influences that govern the education and exposure to medical professionals here. There are 2 approaches the direct and the indirect approach.

The direct approach is carried out under radioscopic control: the needle is

inserted in the centre of the pathologic intersomatic space just before direct

insufflation of the gas mixture.  An expert can do it in about 10

min. After a rest of 10-15 min, the patient can get up and often he/she is

amazed by the disappearance of the pain, as occurs after nucleoplasty. If

necessary, the application can be repeated a second time before changing the


Good results have been obtained after either intradiscal or intraforaminal

injection of a variable volume (3-15 ml) of gas at an O3 concentration of 27-

30 mcg/ml. Several thousand patients have been treated, with a success rate

of 54-86% ( Jucopilla et al., 2000; Bonetti et al., 2001; Fabris et al., 2001;

Petralia et al., 2001; Alexandre et al., 2002). An extensive study had been

performed in 600 patients, who had failed to respond to conservative

management (Andreula et al., 2003): 70.3% of the first half of patients,

treated only with ozone, showed a good outcome. This was further improved

(78.3%) in the remaining 300 patients, by combining ozone treatment with a

periganglionic injection of corticosteroid and anaesthetic. Unfortunately

controls (either oxygen or oxygen-corticosteroid-anaesthetic alone) were not

evaluated, probably, for ethical reasons. Nonetheless, from a scientic point

of view, it will be important to perform a randomized study to evaluate the

role of the needle, oxygen and so forth, which are probably relevant.

It remains unclear how ozone acts. One real possibility, previously

discussed at length (Bocci 1998a, 1999), is that ozone dissolves in the

interstitial water and reacts immediately, generating a cascade of ROS,

among which H2O2 and possibly the hydroxyl radical, which is most

reactive. The hydroxyl radical can react with carbohydrates and amino acids

composing proteoglycans and collagen type I and II, major components of

the degenerate nucleus pulposus, leading to its breakdown (McCord, 1974;

Curran et al., 1984; Hawkins and Davies, 1996; Bocci et al., 2001b;

Leonardi et al., 2001). These studies, as well as those performed on human

blood, have been carried out using the Electron Paramagnetic Resonance

(EPR) spin trapping technique (Ueno et al., 1998; Bocci et al., 2001b).

Consequently, reabsorption of hydrolytic products and water may lead to

progressive shrinkage and disappearance of the herniated material. Reduced

mechanical irritation decreases the sensitivity of nerve axons, but

nociceptors are also excited by endogenous algesic substances released

during perineural ischaemia or neural inflammation present in the spinal

ganglion and neural roots (Willis, 1995). Thus, more than the mechanical

compression as primum movens, it is the inflammatory reaction that

sustains chronic pain by releasing PLA2, several proteinases and

cytokines. The continued release of ROS, PGE2, serotonin, bradykinin,

cathepsins, IL-1, IL-6, substance P and TNF alpha causes oedema, possibly

demyelination and increased excitability of nociceptors (Fields, 1986).


Indeed, it has been observed that, in absence of inflammation, even a large

hernia can be painless. Moreover, the hernia may remain after an operation

(as seen radiographically), but the pain disappears once the inflammatory

disorder dies down. Interestingly, epidural injections of the antiinflammatory

methylprednisolone transitorily improve leg pain and sensory

deficits in patients with sciatica due to a herniated disc (Carette et al., 1997).

Table 7 intends to summarize the complex reparative process induced by

ozone used in substitution or in combination with orthodox remedies.

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Gecko Info Pic

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